Educational content only. Not medical advice. Consult a qualified physician.
Humanin peptide
Anti-AgingResearch-only. Not FDA-approved. Active area of academic research in aging, neurodegeneration, and metabolism. No clinical trials for therapeutic use as of current data.

HN

Humanin

Humanin is a mitochondrial-derived peptide consisting of 24 amino acids, first identified in 2001 from surviving neurons of Alzheimer's disease patients. It is encoded in the mitochondrial genome within the 16S ribosomal RNA gene. Research has focused on its cytoprotective, neuroprotective, and metabolic regulatory properties.
Reported Benefits

Potential Benefits

  • Preclinical research suggests neuroprotective effects against amyloid-beta toxicity
  • Studies indicate potential cytoprotective properties in various cell types
  • May support insulin sensitivity and metabolic health based on animal studies
  • Research suggests anti-apoptotic effects (protection against programmed cell death)
  • Circulating humanin levels decline with age, suggesting potential relevance to aging
Research Dosing

Recommended Starting Dose

Not well-established; research doses vary widely (typically in the microgram range in studies)

Based on published research protocols. Not a prescription.

Dosing Protocol

No established clinical dosing protocol. Research applications use varying doses. Synthetic analogs like HNG (S14G-Humanin) have been studied for enhanced potency. This peptide remains primarily in the research phase.

DOSING INFORMATION DISCLAIMER: Any dosing information, protocols, or ranges discussed on this site are drawn from published research studies and clinical literature. They are presented for educational reference only and must not be used as self-medication guidance.

Research Timeline

Expected Timeline

Phase 1

As a research compound, expected timelines for human benefit are not well-defined. Biomarker studies would be needed to assess effects.

Regulatory

Research Status

Research-only. Not FDA-approved. Active area of academic research in aging, neurodegeneration, and metabolism. No clinical trials for therapeutic use as of current data.

The regulatory status of peptides can change at any time. Verify current FDA classification and legal status in your jurisdiction before seeking medical consultation about this compound.

Safety Profile

Potential Side Effects

  • Very limited human clinical data
  • Safety profile in humans is not established
  • Theoretical concerns about anti-apoptotic effects in cancer cells
  • Long-term effects are unknown
  • Most research is preclinical
Related Research

More in Anti-Aging

Medical Disclaimer

EDUCATIONAL CONTENT ONLY: The peptide information presented on this page is compiled from published scientific literature, peer-reviewed research, and publicly available clinical data. It is provided strictly for educational purposes and does not constitute medical advice, an endorsement of any specific peptide, or a recommendation for treatment. Many peptides discussed on this site have not received FDA approval for human therapeutic use. Some may be under active regulatory review or subject to restrictions on compounding under FDA Section 503A and 503B frameworks. The regulatory status of individual peptides can change at any time. Readers should verify the current legal status of any peptide in their jurisdiction before pursuing further information or consultation. If you are considering peptide therapy, seek guidance from a licensed physician or healthcare provider who specializes in peptide-based treatments and operates within applicable federal and state regulations.